化工社化工社 化学情報印刷レポート · 研究参考用
p-Toluenesulfonic acid → Ethyl (3,4,6-Trifluoro-2-methylbenzoyl)acetate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | p-Toluenesulfonic acid | HCID 6101 | — |
| 反応物 | Diethyl 2-methyl-3,4,6-trifluorobenzoylmalonate | HCID 17879412 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | Ethyl (3,4,6-Trifluoro-2-methylbenzoyl)acetate | HCID 14517129 | 82.6% |
反応手順
To 5.1 g of diethyl 2-methyl-3,4,6-trifluorobenzoylmalonate were added 20 ml of water and 30 mg of p-toluenesulfonic acid, followed by heating and refluxing for 2.5 hours. After cooling, the mixture was extracted with diethyl ether. The extract was dried over magnesium sulfate and concentrated to give 3.3 g of ethyl 2-methyl-3,4,6-trifluorobenzoylacetate.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06333431B1 |
| 出典データセット | uspto-grants-2001_12 |
| ORD ID | ord-991ad80c1386408da891fc79a06e5c96 |
| 出典メモ | uspto-grants-2001_12 |