化工社化工社 化学情報印刷レポート · 研究参考用
Iodine → 4-Quinolinol, 3-iodo-
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Iodine | HCID 807 | — |
| 反応物 | Potassium Hydroxide | HCID 14797 | — |
| 反応物 | 4-Hydroxyquinoline | HCID 69141 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 4-Quinolinol, 3-iodo- | HCID 12376844 | — |
反応手順
1H-Quinolin-4-one (2.90 g, 20 mmol, 1 equiv) in 5 mL of DMF was treated with 1.12 g of KOH (2 equiv) and 5.30 g of iodine (1.05 equiv) for 2 hours. The reaction was quenched by slow addition of saturated aqueous solution of Na2S2O3. Filtration gave 3-iodo-1H-quinolin-4-one as an off-white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07557213B2 |
| 出典データセット | uspto-grants-2009_07 |
| ORD ID | ord-a663a3f815d4412d9d03fca6c3220b1e |
| 出典メモ | uspto-grants-2009_07 |