Hydrochloric Acid → HCID 70676330、化合物

HRID 2271497ノート

反応式

HRID 2271497 の反応式
Cl.[Cl:2][C:3]1[CH:4]=[C:5]([CH:10]([O:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[CH:11]2[CH2:14][N:13](C(OC(C)(C)C)=O)[CH2:12]2)[CH:6]=[CH:7][C:8]=1[Cl:9]>CO>[ClH:2].[Cl:2][C:3]1[CH:4]=[C:5]([CH:10]([O:22][C:23]2[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=2)[CH:11]2[CH2:14][NH:13][CH2:12]2)[CH:6]=[CH:7][C:8]=1[Cl:9]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 70676150HCID 70676150、化合物

生成物 1

HCID 70676330HCID 70676330、化合物収率 97%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
60 °C

実験手順

1N HCl (3 mL) was added to 10 mL of tertiary butyl 3-((3,4-dichlorophenyl)(phenoxy)methyl)azetidine-1-carboxylate (150 mg, 0.352 mmol) dissolved in a methanol solution, and heated to reflux at 60° C. for one day. Thereafter, the solvent of the reaction mixture was removed by reduced pressure evaporation to obtain the title compound.

後処理

  1. temperatureheated
  2. customThereafter, the solvent of the reaction mixture was removed by reduced pressure evaporation

出典と根拠

ORDレコード
ord-93bc20a08d9041a0b7ad8d0f4530eab1
出典データセット
uspto-grants-2015_09
特許番号
US09120771B2

反応ノート

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