1,1'-Biphenyl, mixt. with 1,1'-oxybis(benzene) → HCID 178519813、化合物

HRID 2271523ノート

反応式

HRID 2271523 の反応式
C1C=CC(C2C=CC=CC=2)=CC=1.C1C=CC(OC2C=CC=CC=2)=CC=1.[Br:26][C:27]1[CH:32]=[CH:31][C:30]([NH:33][CH:34]=[C:35]([C:40]([CH:42]2[CH2:44][CH2:43]2)=[O:41])[C:36]([O:38]C)=O)=[CH:29][C:28]=1[F:45]>>[Br:26][C:27]1[CH:32]=[C:31]2[C:30](=[CH:29][C:28]=1[F:45])[N:33]=[CH:34][C:35]([C:40]([CH:42]1[CH2:44][CH2:43]1)=[O:41])=[C:36]2[OH:38]

参加物

3

反応物 2

HCID 246701,1'-Biphenyl, mixt. with 1,1'-oxybis(benzene)HCID 178500751HCID 178500751、化合物

生成物 1

HCID 178519813HCID 178519813、化合物収率 79.2%

実験手順

To Dowtherm at 250° C. was added methyl 3-(4-bromo-3-fluorophenylamino)-2-(cyclopropanecarbonyl)acrylate (7.5 g, 21.9 mmol) portionwise and the reaction mixture was stirred for 1.5 h. The reaction mixture was cooled to room temperature, diluted with hexanes and the resulting precipitate was filtered to afford the desired product (5.38 g, 79%) as a brown solid: ESI MS m/z 311 [C13H9BrFNO2+H]+.

後処理

  1. filtrationthe resulting precipitate was filtered

出典と根拠

ORDレコード
ord-bed88c9d698b4ce4b419c9ddb8b671bb
出典データセット
uspto-grants-2015_09
特許番号
US09120749B2

反応ノート

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