1-(6-Bromo-4-chloroquinolin-3-yl)-3-methylbutan-1-one → HCID 178446971、化合物
反応式
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][C:6]([C:12](=[O:17])[CH2:13][CH:14]([CH3:16])[CH3:15])=[C:5]2Cl.[CH3:19][N:20]([CH3:28])[C@H:21]1[CH2:26][CH2:25][C@H:24]([NH2:27])[CH2:23][CH2:22]1>>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][C:6]([C:12](=[O:17])[CH2:13][CH:14]([CH3:16])[CH3:15])=[C:5]2[NH:27][C@H:24]1[CH2:25][CH2:26][C@H:21]([N:20]([CH3:28])[CH3:19])[CH2:22][CH2:23]1参加物
3
実験手順
Following general procedure B, 1-(6-bromo-4-chloroquinolin-3-yl)-3-methylbutan-1-one (44 mg, 0.14 mmol) was reacted with trans-N1,N1-dimethylcyclohexane-1,4-diamine (92 mg, 0.43 mmol) to afford the desired product (13 mg, 21%) as an off-white solid: ESI MS m/z 433 [C22H30BrN3O+H]+.
出典と根拠
- ORDレコード
- ord-5166f659b25e40a6b57cc51613effa96
- 出典データセット
- uspto-grants-2015_09
- 特許番号
- US09120749B2