Benzyl alcohol, p-amino-alpha-((dimethylamino)methyl)- → HCID 86692894、化合物

HRID 2271670ノート

反応式

HRID 2271670 の反応式
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][C:6]([C:12]([CH:14]1[CH2:16][CH2:15]1)=[O:13])=[C:5]2Cl.[NH2:18][C:19]1[CH:24]=[CH:23][C:22]([CH:25]([OH:30])[CH2:26][N:27]([CH3:29])[CH3:28])=[CH:21][CH:20]=1>>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][C:6]([C:12]([CH:14]1[CH2:16][CH2:15]1)=[O:13])=[C:5]2[NH:18][C:19]1[CH:20]=[CH:21][C:22]([CH:25]([OH:30])[CH2:26][N:27]([CH3:28])[CH3:29])=[CH:23][CH:24]=1

参加物

3

反応物 2

HCID 54334Benzyl alcohol, p-amino-alpha-((dimethylamino)methyl)-HCID 66715111(6-Bromo-4-chloroquinolin-3-yl)(cyclopropyl)methanone

生成物 1

HCID 86692894HCID 86692894、化合物収率 53.5%

実験手順

Following general procedure C, (6-bromo-4-chloroquinolin-3-yl)(cyclopropyl)methanone (240 mg, 0.770 mmol) was reacted with 1-(4-aminophenyl)-2-(dimethylamino)ethanol (139 mg, 0.770 mmol) to afford the desired product (187 mg, 53%) as a yellow solid: ESI MS m/z 454 [C23H24BrN3O2+H]+.

出典と根拠

ORDレコード
ord-746ed678ec8346e480e826340a520686
出典データセット
uspto-grants-2015_09
特許番号
US09120749B2

反応ノート

読み込み中…