3-(2-(Dimethylamino)ethyl)aniline → HCID 68092217、化合物

反応式

[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][C:6]([C:12](=[O:14])[CH3:13])=[C:5]2Cl.[CH3:16][N:17]([CH3:27])[CH2:18][CH2:19][C:20]1[CH:21]=[C:22]([CH:24]=[CH:25][CH:26]=1)[NH2:23]>>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][C:6]([C:12](=[O:14])[CH3:13])=[C:5]2[NH:23][C:22]1[CH:24]=[CH:25][CH:26]=[C:20]([CH2:19][CH2:18][N:17]([CH3:16])[CH3:27])[CH:21]=1

参加物

反応物 2

HCID 287208013-(2-(Dimethylamino)ethyl)aniline

HCID 667154831-(6-Bromo-4-chloroquinolin-3-YL)ethanone

生成物 1

HCID 68092217HCID 68092217、化合物収率 72.8%

実験手順

Following general procedure C, 1-(6-bromo-4-chloroquinolin-3-yl)ethanone (340 mg, 1.20 mmol) was reacted with 3-(2-(dimethylamino)ethyl)aniline (215 mg, 1.31 mmol) to afford the desired product (360 mg, 50%) as a yellow solid: ESI MS m/z 412 [C21H22BrN3O+H]+.

出典と根拠

ORDレコード: ord-5bf41618c7bc4f8aa97350f91c57bd7a
出典データセット: uspto-grants-2015_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09120749B2

反応ノート

読み込み中…