Boron tribromide → 2-Amino-5-bromo-4-methylphenol
反応式
[Br:1][C:2]1[CH:8]=[C:7]([O:9]C)[C:5]([NH2:6])=[CH:4][C:3]=1[CH3:11].B(Br)(Br)Br>C(Cl)Cl>[NH2:6][C:5]1[CH:4]=[C:3]([CH3:11])[C:2]([Br:1])=[CH:8][C:7]=1[OH:9]参加物
4
実験手順
To a suspension of 4-bromo-6-methoxy-3-methylaniline (41) (500 mg, 2.3 mmol) in 6 ml DCM was added 1 M BBr3 in DCM (4.6 ml, 4.6 mmol). The reaction mixture was stirred at r.t. for 2 h, which turned to a brown solution and back to a brown suspension. After quenched with aq. sodium bicarbonate solution, the mixture was extracted with EA. The org. phase was washed with brine, dried over sodium sulfate, concentrated to dryness to give 581 mg 2-amino-5-bromo-4-methylphenol as dark oil.
後処理
- customAfter quenched with aq. sodium bicarbonate solution
- extractionthe mixture was extracted with EA
- washphase was washed with brine
- dry with materialdried over sodium sulfate
- concentrationconcentrated to dryness
出典と根拠
- ORDレコード
- ord-6e4edf1515d642fabb356a3131423ab6
- 出典データセット
- uspto-grants-2015_09
- 特許番号
- US09120751B2
反応ノート
読み込み中…