Triacetoxyperiodinane → 2-(4-Methyl-2-nitro-phenyl)thiazole-4-carbaldehyde

HRID 227238ノート

反応式

HRID 227238 の反応式
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[S:9][CH:10]=[C:11]([CH2:13][OH:14])[N:12]=2)=[C:4]([N+:15]([O-:17])=[O:16])[CH:3]=1.CC(OI1(OC(C)=O)(OC(C)=O)OC(=O)C2C=CC=CC1=2)=O>C(Cl)Cl>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[S:9][CH:10]=[C:11]([CH:13]=[O:14])[N:12]=2)=[C:4]([N+:15]([O-:17])=[O:16])[CH:3]=1

参加物

4

反応物 2

HCID 159087TriacetoxyperiodinaneHCID 690554642-(4-Methyl-2-nitro phenyl)thiazol-4-yl methanol

生成物 1

HCID 866229132-(4-Methyl-2-nitro-phenyl)thiazole-4-carbaldehyde

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

2-(4-Methyl-2-nitro phenyl)thiazol-4-yl methanol (297 mg, 1.18 mmol) was stirred in 5 mL of CH2Cl2 at room temperature under N2. The Dess-Martin reagent (500 mg, 1.18 mmol) was added as a solid. After 30 minutes, the reaction was complete. The reaction was diluted to 60 mL of CH2Cl2 and washed with 60 mL of 1N NaOH. The organics were dried over MgSO4, filtered and concentrated under reduced pressure. The crude material was purified on a biotage column 12M eluted with EtOAc/hexanes 1:4 to give the desired material.

後処理

  1. washwashed with 60 mL of 1N NaOH
  2. dry with materialThe organics were dried over MgSO4
  3. filtrationfiltered
  4. concentrationconcentrated under reduced pressure
  5. customThe crude material was purified on a biotage column 12M
  6. washeluted with EtOAc/hexanes 1:4

出典と根拠

ORDレコード
ord-7426a613c0704460af664f96b279241b
出典データセット
uspto-grants-2009_07
特許番号
US07560462B2

反応ノート

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