化工社化工社 化学情報印刷レポート · 研究参考用
3-(1,2,3,6-Tetrahydropyridin-4-yl)-1H-indole → 3-(4-Piperidinyl)-1H-indole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-(1,2,3,6-Tetrahydropyridin-4-yl)-1H-indole | HCID 2761023 | — |
| 触媒 | Palladium | HCID 23938 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 3-(4-Piperidinyl)-1H-indole | HCID 702235 | — |
反応手順
19.03 g (0.096 mol) of 3-(1,2,3,6-tetrahydro-pyridin-4-yl)-1H-indole were hydrogenated in a Parr apparatus during 18 h at 3 bar with 2.2 g of Pd/C 10% in 600 ml of methanol. After standard work-up, 16.76 g (87% of yield) of the desired product were obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07560471B2 |
| 出典データセット | uspto-grants-2009_07 |
| ORD ID | ord-82f1ca6314c24c078bf152d40688e60d |
| 出典メモ | uspto-grants-2009_07 |