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HRID 227276作成日：2026年10月26日
Potassium Carbonate → 5-[4-(6-fluoro-1H-indol-3-yl)-piperidin-1-ylmethyl]2-methoxybenzoic acid ethyl ester
https://huagongshe.com/reaction/227276
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 6-fluoro-3-(piperidin-4-yl)-1H-indole | HCID 11096077 | — |
| 反応物 | Methyl 5-(bromomethyl)-2-methoxybenzoate | HCID 19744340 | — |
| 溶媒 | 5-Methylhexan-3-one | HCID 12187 | — |
| 生成物 | 5-[4-(6-fluoro-1H-indol-3-yl)-piperidin-1-ylmethyl]2-methoxybenzoic acid ethyl ester | HCID 68894051 | — |
反応手順
A suspension containing 0.5 g (2.2 mmol) of 6-fluoro-3-piperidin-4-yl-1H-indole, 0.8 g (2.7 mmol) of 5-bromomethyl-2-methoxy-benzoic acid methyl ester and 0.6 g (4.3 mmol) of potassium carbonate in 10 ml of ethyl isobutylketone was heated at 90° C. for 16 hours. The inorganic solid was filtrated and the solvent was removed under reduced pressure. 0.91 g (97% of yield) of the expected product was obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US07560471B2 |
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| 出典データセット | uspto-grants-2009_07 |
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| ORD ID | ord-7d00d126e7a8487a94795ac614c72bf1 |
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| 出典メモ | uspto-grants-2009_07 |
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