Ethanol → 2,5,7-Triazaspiro[3.4]octane-6,8-dione
反応式
C(OC([N:8]1[CH2:11][C:10](=O)[CH2:9]1)=O)(C)(C)C.[C-]#N.[K+].[C:16](=[O:19])([O-])[O-].[NH4+:20].[NH4+:21].[CH2:22]([OH:24])C>O>[CH2:11]1[C:10]2([NH:21][C:22](=[O:24])[NH:20][C:16]2=[O:19])[CH2:9][NH:8]1参加物
6
反応条件
- 温度
- 90 °C
実験手順
3-Oxo-azetidine-1-carboxylic acid tert-butyl ester (1 eq.) and potassium cyanide (1.3 eq) are dissolved in ethanol before ammonium carbonate (8 eq.) in water is added. The mixture is heated to 90° C. for 19 h and monitored by LCMS. Upon completion, the solvent is removed in vacuum. The residue is diluted with water and the product filtered off. Boc-deprotection under standard conditions gives the desired hydantoine as HCl-salt ready for further modifications.
後処理
- additionis added
- customUpon completion, the solvent is removed in vacuum
- additionThe residue is diluted with water
- filtrationthe product filtered off
出典と根拠
- ORDレコード
- ord-350c788c2115403eb7d378c904a62964
- 出典データセット
- uspto-grants-2015_09
- 特許番号
- US09120804B2
反応ノート
読み込み中…