Ethanol → 1,3,7-Triazaspiro[4.5]decane-2,4-dione

HRID 2273022ノート

反応式

HRID 2273022 の反応式
C(OC([N:8]1[CH2:13][CH2:12][CH2:11][C:10](=O)[CH2:9]1)=O)(C)(C)C.[C-]#N.[K+].[C:18](=[O:21])([O-])[O-].[NH4+:22].[NH4+:23].[CH2:24]([OH:26])C>O>[C:18]1(=[O:21])[C:10]2([CH2:9][NH:8][CH2:13][CH2:12][CH2:11]2)[NH:23][C:24](=[O:26])[NH:22]1

参加物

6

反応物 4

HCID 702EthanolHCID 9032Potassium CyanideHCID 517111Ammonium CarbonateHCID 2756825Tert-butyl 3-oxopiperidine-1-carboxylate

生成物 1

HCID 126522631,3,7-Triazaspiro[4.5]decane-2,4-dione

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
90 °C

実験手順

3-Oxo-piperidine-1-carboxylic acid tert-butyl ester and potassium cyanide (1.3 eq) are dissolved in ethanol before ammonium carbonate (8 eq.) in water is added. The mixture is heated to 90° C. for 2 h and monitored by LCMS. Upon completion, the solvent is removed in vacuum. The residue is diluted with water and the product filtered off. Boc-deprotection under standard conditions gives the desired hydantoine as HCl-salt ready for further modifications.

後処理

  1. additionis added
  2. customUpon completion, the solvent is removed in vacuum
  3. additionThe residue is diluted with water
  4. filtrationthe product filtered off

出典と根拠

ORDレコード
ord-f264eaad28044afbb68239437130b56a
出典データセット
uspto-grants-2015_09
特許番号
US09120804B2

反応ノート

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