Hydrochloric Acid → 6-(5-Fluoro-3-methyl-benzofuran-2-sulfonyl)-2H-pyridazin-3-one

HRID 22738

反応式

HRID 22738 の反応式
C[O:2][C:3]1[N:4]=[N:5][C:6]([S:9]([C:12]2[O:13][C:14]3[CH:21]=[CH:20][C:19]([F:22])=[CH:18][C:15]=3[C:16]=2[CH3:17])(=[O:11])=[O:10])=[CH:7][CH:8]=1.Cl>O1CCOCC1>[F:22][C:19]1[CH:20]=[CH:21][C:14]2[O:13][C:12]([S:9]([C:6]3[CH:7]=[CH:8][C:3](=[O:2])[NH:4][N:5]=3)(=[O:11])=[O:10])=[C:16]([CH3:17])[C:15]=2[CH:18]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 116239443-Methoxy-6-(5-fluoro-3-methyl-benzofuran-2-sulfonyl)-pyridazine

生成物 1

HCID 99663686-(5-Fluoro-3-methyl-benzofuran-2-sulfonyl)-2H-pyridazin-3-one収率 84%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

反応条件

温度
100 °C

実験手順

A mixture of 3-methoxy-6-(5-fluoro-3-methyl-benzofuran-2-sulfonyl)-pyridazine (2.4 mmol, 775 mg), conc. HCl (1.5 mL), and dioxane (3 mL) was heated at 100° C. for 2 hours. The reaction mixture was cooled and evaporated to dryness. The dried residue was triturated with water (10 mL), and filtered to obtain the desired product, 6-(5-fluoro-3-methyl-benzofuran-2-sulfonyl)-2H-pyridazin-3-one (84%, 620 mg); mp 232° C.-233° C.

後処理

  1. temperatureThe reaction mixture was cooled
  2. customevaporated to dryness
  3. customThe dried residue was triturated with water (10 mL)
  4. filtrationfiltered

出典と根拠

ORDレコード
ord-a1c3f1ffc1dd4efbb8f8bd92f4d3fe3d
出典データセット
uspto-grants-2005_02
特許番号
US06849629B2

関連ノート

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