Methyl 5-Amino-2-chlorobenzoate → methyl 2-chloro-5-({[1-methyl-3-(pentafluoroethyl)-4-(trifluoromethyl)-1H-pyrazol-5-yl]carbonyl}amino)benzoate

HRID 2274012ノート

反応式

HRID 2274012 の反応式
[CH3:1][N:2]1[C:6]([C:7](Cl)=[O:8])=[C:5]([C:10]([F:13])([F:12])[F:11])[C:4]([C:14]([F:20])([F:19])[C:15]([F:18])([F:17])[F:16])=[N:3]1.[NH2:21][C:22]1[CH:23]=[CH:24][C:25]([Cl:32])=[C:26]([CH:31]=1)[C:27]([O:29][CH3:30])=[O:28]>ClCCl.[Ag]C#N>[Cl:32][C:25]1[CH:24]=[CH:23][C:22]([NH:21][C:7]([C:6]2[N:2]([CH3:1])[N:3]=[C:4]([C:14]([F:19])([F:20])[C:15]([F:17])([F:18])[F:16])[C:5]=2[C:10]([F:12])([F:13])[F:11])=[O:8])=[CH:31][C:26]=1[C:27]([O:29][CH3:30])=[O:28]

参加物

5

反応物 2

HCID 5200412Methyl 5-Amino-2-chlorobenzoateHCID 866600741-methyl-3-(pentafluoroethyl)-4-(trifluoromethyl)-1H-pyrazole-5-carbonyl chloride

生成物 1

HCID 86660079methyl 2-chloro-5-({[1-methyl-3-(pentafluoroethyl)-4-(trifluoromethyl)-1H-pyrazol-5-yl]carbonyl}amino)benzoate

試薬・触媒・溶媒 2

HCID 178509332CID 101611454触媒HCID 6344Dichloromethane溶媒2 回

実験手順

A solution of 4.24 g (12.8 mmol) of 1-methyl-3-(pentafluoroethyl)-4-(trifluoromethyl)-1H-pyrazole-5-carbonyl chloride in 25 ml of dichloromethane p.a. is added to a suspension of 2.38 g (12.8 mmol) of methyl 5-amino-2-chlorobenzoate and 2.57 g (19.2 mmol) of silver(I) cyanide in 50 ml of dichlormethane p.a., and the mixture is stirred at room temperature for 16 h. The suspension is then filtered through silica gel and the product is eluted using a mixture of cyclohexane and ethyl acetate (1:1). The organic phase is washed successively three times with 6N hydrochloric acid and twice with saturated sodium chloride solution. The organic phase is then dried over sodium sulphate, filtered and concentrated on a rotary evaporator under reduced pressure. This gives 5.75 g (93%) of methyl 2-chloro-5-({[1-methyl-3-(pentafluoroethyl)-4-(trifluoromethyl)-1H-pyrazol-5-yl]carbonyl}amino)benzoate.

後処理

  1. filtrationThe suspension is then filtered through silica gel
  2. washthe product is eluted
  3. additiona mixture of cyclohexane and ethyl acetate (1:1)
  4. washThe organic phase is washed successively three times with 6N hydrochloric acid
  5. dry with materialThe organic phase is then dried over sodium sulphate
  6. filtrationfiltered
  7. concentrationconcentrated on a rotary evaporator under reduced pressure

出典と根拠

ORDレコード
ord-946cc60b37e244af9d34224f11fde5de
出典データセット
uspto-grants-2015_09
特許番号
US09126945B2

反応ノート

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