Morpholine → 6-fluoro-7-morpholin-4-yl-3H-quinazolin-4-one

反応式

[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1F)[N:8]=[CH:7][NH:6][C:5]2=[O:13].[NH:14]1[CH2:19][CH2:18][O:17][CH2:16][CH2:15]1>>[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[N:14]1[CH2:19][CH2:18][O:17][CH2:16][CH2:15]1)[N:8]=[CH:7][NH:6][C:5]2=[O:13]

参加物

反応物 2

HCID 8083Morpholine

HCID 1354713086,7-Difluoroquinazolin-4(3H)-one

生成物 1

HCID 1360002446-fluoro-7-morpholin-4-yl-3H-quinazolin-4-one収率 74.8%

反応条件

温度: 80 °C

実験手順

37.2 g (0.20 mol) of 6,7-difluoro-3H-quinazolin-4-one were suspended in 70 ml (0.80 mol) of morpholine and stirred at an internal temperature of 80° C. for 16 h. Conventional work-up gave 37.3 g (Y=74%) of 6-fluoro-7-morpholin-4-yl-3H-quinazolin-4-one.

出典と根拠

ORDレコード: ord-d8bd7c471e8e43ab91c17c69264068a9
出典データセット: uspto-grants-2015_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09126952B2

反応ノート

読み込み中…