関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 2-Chloro-N4-methylpyrimidine-4,5-diamine | HCID 7147172 | — |
| 反応物 | Ethyl (3,5-dimethoxyphenyl)(oxo)acetate | HCID 24722256 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 2-chloro-6-(3,5-dimethoxyphenyl)-8-methylpteridin-7(8H)-one | HCID 86713572 | 55.4% |
反応手順
A mixture of ethyl 2-(3,5-dimethoxyphenyl)-2-oxoacetate (1 g, 4.2 mmol) and 2-chloro-N4-methylpyrimidine-4,5-diamine (600 mg, 3.8 mmol) in ethanol (100 mL) and acetic acid (2.5 mL) was stirred at 80° C. for 48 h and cooled to RT (5° C.). The mixture was diluted with dichloromethane and washed with brine. The organic layer was directly concentrated and purified by chromatography on silica gel to give the title compound (700 mg, 50%). MS (ES+) C15H13ClN4O3 requires: 332, 334. Found: 333, 335 [M+H]+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US09126951B2 |
|---|
| 出典データセット | uspto-grants-2015_09 |
|---|
| ORD ID | ord-a7dbd190585b47af922a2a81299655ac |
|---|
| 出典メモ | uspto-grants-2015_09 |
|---|
