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Potassium Carbonate → 4-chloro-2-iodo O-crotyl phenol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 2-Butene, 1-bromo- | HCID 122414 | — |
| 反応物 | 4-Chloro-2-iodophenol | HCID 620234 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 4-chloro-2-iodo O-crotyl phenol | HCID 69874042 | 95.1% |
反応手順
To a mixture of 4-chloro-2-iodo phenol (5.11 mmol, 1.3 g) in DMF (40 mL) and potassium carbonate (10 mmol, 1.4 g) was added crotyl bromide (10.2 mmol, 1.6 g) and the reaction mixture was stirred at room temperature for one hour. The reaction was quenched with H2O (100 mL) and extracted with EtOAc (2×50 mL). The EtOAc layer was collected, dried, filtered and the filtrate was evaporated to obtain 4-chloro-2-iodo O-crotyl phenol (94%, 1.5 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06849629B2 |
| 出典データセット | uspto-grants-2005_02 |
| ORD ID | ord-f5692c16398741cabed348cb70f8d640 |
| 出典メモ | uspto-grants-2005_02 |