Dimethylformamide → 5-Chlorothieno[3,2-b]pyridine-3-carbaldehyde

温度

90 °C

To a solution of phosphoryl chloride (14.9 ml, 160 mmol) in dimethylformamide (45 ml) was added portionwise N-(2-oxotetrahydrothiophen-3-yl)acetamide (12.74 g, 80 mmol) and the mixture was stirred at 90° C. for 2 hr. The reaction mixture was poured into ice water (400 ml) and followed by addition of saturated sodium acetate (500 ml). The solution was extracted by ethyl acetate (1000 ml). The organic layer was washed with water (300 ml), water (400 ml) and brine (200 ml). Then the organic layer was dried over magnesium sulfate, filtered and the filtrate was concentrated in vacuo. The residue was crystallized by addition of ethyl acetate/ether (1:1, 200 ml) and the crystals were collected by filtration to obtain the title compound (3.55 g, 18%).

1. extractionThe solution was extracted by ethyl acetate (1000 ml)
2. washThe organic layer was washed with water (300 ml), water (400 ml) and brine (200 ml)
3. dry with materialThen the organic layer was dried over magnesium sulfate
4. filtrationfiltered
5. concentrationthe filtrate was concentrated in vacuo
6. customThe residue was crystallized by addition of ethyl acetate/ether (1:1, 200 ml)
7. filtrationthe crystals were collected by filtration

ORDレコード

ord-2d4e03d39535472ab1ec8d9ca3908b16

出典データセット

uspto-grants-2015_09

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US09126981B2