5,6-difluoro-3-iodo-1-(phenylsulfonyl)-1H-indole → 3-iodo-1-(phenylsulfonyl)-6-(trifluoromethyl)-1H-indole
反応式
FC1C=C2C(=CC=1F)N([S:12]([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)(=[O:14])=[O:13])C=C2I.[I:22][C:23]1[C:31]2[C:26](=[CH:27][C:28]([C:32]([F:35])([F:34])[F:33])=[CH:29][CH:30]=2)[NH:25][CH:24]=1>>[I:22][C:23]1[C:31]2[C:26](=[CH:27][C:28]([C:32]([F:33])([F:35])[F:34])=[CH:29][CH:30]=2)[N:25]([S:12]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)(=[O:14])=[O:13])[CH:24]=1参加物
3
実験手順
Following the general method as outlined in Intermediate 28, starting from 3-iodo-6-(trifluoromethyl)-1H-indole (Intermediate 39; 1.60 g; 5.14 mmol), 1.06 g (45%) of the title compound was obtained as a yellow solid.
出典と根拠
- ORDレコード
- ord-50b14541b5194c119e1a5499af2d589e
- 出典データセット
- uspto-grants-2015_09
- 特許番号
- US09126984B2
反応ノート
読み込み中…