Phosphorus oxychloride → 3-(Propan-2-yl)benzonitrile

HRID 2274939

反応式

HRID 2274939 の反応式
[CH:1]([C:4]1[CH:5]=[C:6]([CH:10]=[CH:11][CH:12]=1)[C:7]([NH2:9])=O)([CH3:3])[CH3:2].O=P(Cl)(Cl)Cl>>[CH:1]([C:4]1[CH:5]=[C:6]([CH:10]=[CH:11][CH:12]=1)[C:7]#[N:9])([CH3:3])[CH3:2]

参加物

3

反応物 2

HCID 24813Phosphorus oxychlorideHCID 2579543-(Propan-2-yl)benzamide

生成物 1

HCID 2584403-(Propan-2-yl)benzonitrile収率 80.4%

実験手順

A solution of the above amide (4.20 g, 25.7 mmol) in POCl3 (36.0 g, 236 mmol) was stirred at 80° C. for 18 h. The solution was concentrated and the residue was poured into water (100 mL). The mixture was exacted with EtOAc. The organic layers were combined, washed by brine, dried over Na2SO4 and concentrated to give 3-isopropyl-benzonitrile (3.00 g, 80%).

後処理

  1. concentrationThe solution was concentrated
  2. additionthe residue was poured into water (100 mL)
  3. washwashed by brine
  4. dry with materialdried over Na2SO4
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-d7d3c1cee680421789a3efc937f0a776
出典データセット
uspto-grants-2015_09
特許番号
US09126993B2

関連ノート

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