関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 2-Propanone, methylhydrazone | HCID 79840 | — |
| 反応物 | 3-(Ethoxymethylene)pentane-2,4-dione | HCID 240418 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | 3-((1-Methyl-2-(propan-2-ylidene)hydrazinyl)methylene)pentane-2,4-dione | HCID 23635272 | — |
反応手順
3-(ethoxymethylene)pentane-2,4-dione (Preparation 2, 8.6 g) was dissolved in Ether (30 mL) and cooled to 0° C. The reaction solution was then slowly treated with 1-methyl-2-(propan-2-ylidene)hydrazine (Preparation 1, 4.8 g) dropwise over 5 minutes, and then warmed and stirred at room temperature overnight. The reaction solution was purified directly by flash column chromatography (Biotage Quad 25; Eluent: 20% EtOH in EtOAc) to afford the title compound as a light red solid. (9.1 g, 84.0%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US09126999B2 |
|---|
| 出典データセット | uspto-grants-2015_09 |
|---|
| ORD ID | ord-dd42a8b98f1940ffbbe97bea0aee796b |
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| 出典メモ | uspto-grants-2015_09 |
|---|
