Hydrochloric Acid → (R)-(3-Aminopiperidin-1-yl)(7-methoxy-1-methyl-2-(1-(2,2,2-trifluoroethyl)-1H-pyrrolo[2,3-b]pyridin-2-yl)-1H-benzo[d]imidazol-5-yl)methanone, hydrochloride

HRID 2275049ノート

反応式

HRID 2275049 の反応式
[NH2:1][C@@H:2]1[CH2:7][CH2:6][CH2:5][N:4]([C:8]([C:10]2[CH:33]=[C:32]([O:34][CH3:35])[C:13]3[N:14]([CH3:31])[C:15]([C:17]4[N:25]([CH2:26][C:27]([F:30])([F:29])[F:28])[C:20]5=[N:21][CH:22]=[CH:23][CH:24]=[C:19]5[CH:18]=4)=[N:16][C:12]=3[CH:11]=2)=[O:9])[CH2:3]1.[ClH:36]>C(Cl)Cl>[ClH:36].[NH2:1][C@@H:2]1[CH2:7][CH2:6][CH2:5][N:4]([C:8]([C:10]2[CH:33]=[C:32]([O:34][CH3:35])[C:13]3[N:14]([CH3:31])[C:15]([C:17]4[N:25]([CH2:26][C:27]([F:30])([F:29])[F:28])[C:20]5=[N:21][CH:22]=[CH:23][CH:24]=[C:19]5[CH:18]=4)=[N:16][C:12]=3[CH:11]=2)=[O:9])[CH2:3]1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 73052940(R)-(3-Aminopiperidin-1-yl)(7-methoxy-1-methyl-2-(1-(2,2,2-trifluoroethyl)-1H-pyrrolo[2,3-b]pyridin-2-yl)-1H-benzo[d]imidazol-5-yl)methanone

生成物 1

HCID 131733421(R)-(3-Aminopiperidin-1-yl)(7-methoxy-1-methyl-2-(1-(2,2,2-trifluoroethyl)-1H-pyrrolo[2,3-b]pyridin-2-yl)-1H-benzo[d]imidazol-5-yl)methanone, hydrochloride収率 102.6%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

(R)-(3-Aminopiperidin-1-yl)(7-methoxy-1-methyl-2-(1-(2,2,2-trifluoroethyl)-1H-pyrrolo[2,3-b]pyridin-2-yl)-1H-benzo[d]imidazol-5-yl)methanone (1.5073 g) was dissolved in DCM (5 ml) and HCl (2M in diethyl ether) (1.5 ml, 3.00 mmol) was added to the solution. The solvent was then removed under nitrogen and concentrated under vacuum to afford the title compound as a white solid (1.61 g)

後処理

  1. customThe solvent was then removed under nitrogen
  2. concentrationconcentrated under vacuum

出典と根拠

ORDレコード
ord-b7ce77abccff4a6b8331b11354f0e5dc
出典データセット
uspto-grants-2015_09
特許番号
US09127003B2

反応ノート

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