HCID 11728150、化合物 → HCID 66834132、化合物

HRID 2275151ノート

反応式

HRID 2275151 の反応式
[CH3:1][C:2]1([CH3:28])[C:14]2[NH:13][C:12]3[C:7](=[CH:8][CH:9]=[C:10]([C:15]#[N:16])[CH:11]=3)[C:6]=2[C:5](=[O:17])[C:4]2[CH:18]=[CH:19][C:20]([CH:22]3[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]3)=[CH:21][C:3]1=2.[N:29]1([S:34](N2C=C[N+](C)=C2)(=[O:36])=[O:35])[CH:33]=[CH:32][N:31]=[CH:30]1>>[N:29]1([S:34]([N:25]2[CH2:26][CH2:27][CH:22]([C:20]3[CH:19]=[CH:18][C:4]4[C:5](=[O:17])[C:6]5[C:7]6[C:12](=[CH:11][C:10]([C:15]#[N:16])=[CH:9][CH:8]=6)[NH:13][C:14]=5[C:2]([CH3:28])([CH3:1])[C:3]=4[CH:21]=3)[CH2:23][CH2:24]2)(=[O:36])=[O:35])[CH:33]=[CH:32][N:31]=[CH:30]1

参加物

3

反応物 2

HCID 11728150HCID 11728150、化合物HCID 668339956,6-dimethyl-11-oxo-8-piperidin-4-yl-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile

生成物 1

HCID 66834132HCID 66834132、化合物収率 22.2%

実験手順

According to the method disclosed in Journal of Organic Chemistry, 2003, page 115, 6,6-dimethyl-11-oxo-8-piperidin-4-yl-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile (Compound B3-13-2, 10 mg, 0.027 mmol) was reacted with 3-(imidazole-1-sulfonyl)-1-methyl-3H-imidazol-1-ium (19 mg, 2 eq.). After removing the solvent, the residues were purified by liquid chromatography to obtain the title compound (3 mg).

後処理

  1. customAfter removing the solvent
  2. customthe residues were purified by liquid chromatography

出典と根拠

ORDレコード
ord-723b790f5faa4867824a10df92f9795f
出典データセット
uspto-grants-2015_09
特許番号
US09126931B2

反応ノート

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