2-(1-Benzo[b]thiophen-2-yl-1-methylethyl)-4-methoxy-benzoic acid → HCID 66835213、化合物

HRID 2275242ノート

反応式

HRID 2275242 の反応式
[S:1]1[C:5]([C:6]([C:9]2[CH:17]=[C:16]([O:18][CH3:19])[CH:15]=[CH:14][C:10]=2[C:11]([OH:13])=O)([CH3:8])[CH3:7])=[CH:4][C:3]2[CH:20]=[CH:21][CH:22]=[CH:23][C:2]1=2>O>[CH3:19][O:18][C:16]1[CH:17]=[C:9]2[C:10](=[CH:14][CH:15]=1)[C:11](=[O:13])[C:4]1[C:3]3[CH:20]=[CH:21][CH:22]=[CH:23][C:2]=3[S:1][C:5]=1[C:6]2([CH3:7])[CH3:8]

参加物

3

反応物 1

HCID 668347002-(1-Benzo[b]thiophen-2-yl-1-methylethyl)-4-methoxy-benzoic acid

生成物 1

HCID 66835213HCID 66835213、化合物収率 63%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
100 °C

実験手順

To 2-(1-benzo[b]thiophen-2-yl-1-methylethyl)-4-methoxy-benzoic acid (Compound Z4, 68 mg, 0.22 mmol), polyphosphoric acid (3.5 g) was added, and the mixture was stirred for 1 hr at 100° C. under heating. The mixture was added with water, extracted with ethyl acetate and washed with water. The organic layer was dried over magnesium sulfate. The residues obtained after concentration under reduced pressure were purified by silica gel column chromatography (ethyl acetate/hexane) to obtain the title compound (41 mg, 63%).

後処理

  1. temperatureunder heating
  2. extractionextracted with ethyl acetate
  3. washwashed with water
  4. dry with materialThe organic layer was dried over magnesium sulfate
  5. customThe residues obtained
  6. concentrationafter concentration under reduced pressure
  7. customwere purified by silica gel column chromatography (ethyl acetate/hexane)

出典と根拠

ORDレコード
ord-ad567e89495644fdbe895f522bc5c5ca
出典データセット
uspto-grants-2015_09
特許番号
US09126931B2

反応ノート

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