2-Tert-butylpropanedioic acid → 4-(6-Methoxy-pyridin-2-yl)-4-methyl-3-oxo-pentanoic acid tert-butyl ester

HRID 2275273ノート

反応式

HRID 2275273 の反応式
[CH3:1][O:2][C:3]1[N:8]=[C:7]([C:9]([CH3:14])([CH3:13])[C:10]([OH:12])=O)[CH:6]=[CH:5][CH:4]=1.C([CH:19]([C:23]([OH:25])=[O:24])C(O)=O)(C)(C)C>>[C:9]([O:25][C:23](=[O:24])[CH2:19][C:10](=[O:12])[C:9]([C:7]1[CH:6]=[CH:5][CH:4]=[C:3]([O:2][CH3:1])[N:8]=1)([CH3:14])[CH3:13])([CH3:13])([CH3:10])[CH3:7]

参加物

3

反応物 2

HCID 2427522-Tert-butylpropanedioic acidHCID 668349942-(6-Methoxypyridin-2-yl)-2-methylpropanoic acid

生成物 1

HCID 668345394-(6-Methoxy-pyridin-2-yl)-4-methyl-3-oxo-pentanoic acid tert-butyl ester

実験手順

The title compound was synthesized from 2-(6-methoxy-pyridin-2-yl)-2-methyl-propionic acid and mono-tert-butyl malonic acid according to the method used for the synthesis of Compound PR4. The resultant was used for the next step without further purification.

後処理

  1. customused for the synthesis of Compound PR4
  2. customThe resultant was used for the next step without further purification

出典と根拠

ORDレコード
ord-c8c729664cae41a19f9f987239398a62
出典データセット
uspto-grants-2015_09
特許番号
US09126931B2

反応ノート

読み込み中…