化工社化工社 化学情報印刷レポート · 研究参考用
Hydrochloric Acid → Donepezil Hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Donepezil | HCID 3152 | — |
| 反応物 | Diisopropyl Ether | HCID 7914 | — |
| 溶媒 | 1,2-Dichloroethane | HCID 11 | — |
| 生成物 | Donepezil Hydrochloride | HCID 5741 | — |
反応手順
Donepezil free base (4.0 gm) is dissolved in ethylene dichloride (20 ml) at 27° C., conc. hydrochloric acid (1.2 ml) is added to the solution and stirred for 2 hours at 25° C. to 30° C. Then diisopropyl ether (75 ml) is added and the precipitated solid is filtered off and dried to give 3.0 gm of donepezil hydrochloride form H1.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07560560B2 |
| 出典データセット | uspto-grants-2009_07 |
| ORD ID | ord-526665e5b2a6411daa8886dec93bd9b1 |
| 出典メモ | uspto-grants-2009_07 |