化工社化工社 化学情報印刷レポート · 研究参考用
Hydrochloric Acid → Donepezil Hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Donepezil | HCID 3152 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | Donepezil Hydrochloride | HCID 5741 | — |
反応手順
Donepezil free base (10.0 gm) is dissolved in toluene (50 ml) at 25° C., conc. hydrochloric acid (2.8 ml) is added to the solution and stirred for 6 hours at 25° C. to 30° C. The crystals formed are filtered and dried to give 8.2 gm of donepezil hydrochloride form H2.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07560560B2 |
| 出典データセット | uspto-grants-2009_07 |
| ORD ID | ord-59976aee61b74cbba743bbba07a40700 |
| 出典メモ | uspto-grants-2009_07 |