Hydrochloric Acid → HCID 86717923、化合物
反応式
[N:1]1([CH:6]2[CH2:9][N:8]([CH2:10][CH2:11][NH:12]C(=O)OC(C)(C)C)[CH2:7]2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[ClH:20]>C(OCC)C.O1CCOCC1>[ClH:20].[ClH:20].[N:1]1([CH:6]2[CH2:9][N:8]([CH2:10][CH2:11][NH2:12])[CH2:7]2)[CH2:2][CH2:3][CH2:4][CH2:5]1参加物
5
実験手順
460 mg of tert-butyl {2-[3-(pyrrolidin-1-yl)azetidin-1-yl]ethyl}carbamate (Example 220A, 1.7 mmol, 1 equivalent) were initially charged in 8.54 ml of 2 N hydrochloric acid in diethyl ether and 1 ml of dioxane, and the mixture was stirred at RT overnight. The precipitated solid was filtered off, washed with diethyl ether and dried under reduced pressure. This gave 390 mg (94% of theory) of the title compound.
後処理
- filtrationThe precipitated solid was filtered off
- washwashed with diethyl ether
- customdried under reduced pressure
出典と根拠
- ORDレコード
- ord-f45286ffa4734ee8827aabdcb0be10f2
- 出典データセット
- uspto-grants-2015_09
- 特許番号
- US09126998B2
反応ノート
読み込み中…