Hydrochloric Acid → HCID 88415079、化合物

HRID 2275853ノート

反応式

HRID 2275853 の反応式
[ClH:1].[NH2:2][C:3]([CH3:17])([C:13]([F:16])([F:15])[F:14])[CH2:4][NH:5]C(=O)OC(C)(C)C>O1CCOCC1>[ClH:1].[ClH:1].[F:14][C:13]([F:16])([F:15])[C:3]([CH3:17])([NH2:2])[CH2:4][NH2:5]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 90136051rac-tert-Butyl (2-amino-3,3,3-trifluoro-2-methylpropyl)carbamate

生成物 1

HCID 88415079HCID 88415079、化合物

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒2 回

実験手順

188 ml of 4 M hydrogen chloride in dioxane were added to 15 g (61.9 mmol) of rac-tert-butyl (2-amino-3,3,3-trifluoro-2-methylpropyl)carbamate from Example 245A in dioxane (188 ml). The reaction mixture was stirred at RT for 16 h and then concentrated and kept under argon. This gave 14.4 g (108% of theory) of the target compound which was not purified any further.

後処理

  1. concentrationconcentrated
  2. customThis gave 14.4 g (108% of theory) of the target compound which was not purified any further

出典と根拠

ORDレコード
ord-b67c0ac48e074a4e9172ca4c5ef8b0c1
出典データセット
uspto-grants-2015_09
特許番号
US09126998B2

反応ノート

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