Triethylamine → 1,2a,4,5,6,6a,7,7a-Octahydrocyclobuta[a]inden-2-one

HRID 2275995

反応式

HRID 2275995 の反応式
[CH2:1]([CH:4]1[CH2:9][CH2:8][CH2:7][CH2:6][C:5]1=[CH:10][C:11]([OH:13])=O)[CH:2]=[CH2:3].C(N(CC)CC)C>ClCCl>[CH2:3]1[CH:2]2[CH2:1][CH:4]3[C:5]([CH:10]2[C:11]1=[O:13])=[CH:6][CH2:7][CH2:8][CH2:9]3

参加物

4

反応物 2

HCID 8471TriethylamineHCID 2785322-(2-Allylcyclohexylidene)acetic acid

生成物 1

HCID 139474001,2a,4,5,6,6a,7,7a-Octahydrocyclobuta[a]inden-2-one収率 83.3%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

A solution of 2-(2-allylcyclohexylidene)acetic acid (800 mg, 4.44 mmol) in dichloromethane (200 mL) was added Ghosez reagent (5.77 mmol, 0.795 mL) at room temperature. The solution was stirred for 45 min until the acid chloride was formed. Then N,N-dimethylaminopyridine (55 mg, 0.45 mmol) was added and the solution was heated to reflux. A solution of triethylamine (8.9 mmol, 1.25 mL) in dichloromethane (3.75 mL) was added dropwise over 30 min. The solution was refluxed for another 1 h and solvent was distilled off. Purification by flash chromatography (pentane/Et2O 95/5) gave 1,2a,4,5,6,6a,7,7a-octahydrocyclobuta[a]inden-2-one (600 mg, 83%) as a colourless liquid, with 20% of the tetrasubstituted regioisomere. 1H NMR (400 MHz, CDCl3) 5.59 (1H, brs), 3.92 (1H, brs), 3.21 (1H, dddd), 2.92 (1H, m), 2.73 (1H, m), 2.51 (1H, m), 2.04 (4H, m), 1.79 (1H, m), 1.48 (2H, m), 1.05 (1H, m).

後処理

  1. customwas formed
  2. temperaturethe solution was heated to reflux
  3. temperatureThe solution was refluxed for another 1 h
  4. distillationsolvent was distilled off
  5. customPurification by flash chromatography (pentane/Et2O 95/5)

出典と根拠

ORDレコード
ord-2d33d8b10de54dcb9df9bf62cac0c033
出典データセット
uspto-grants-2015_09
特許番号
US09131688B2

関連ノート

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