Methylhydrazine → methyl 5-(2-chloro-4-fluorophenyl)-1,3-dimethyl-1H-pyrazole-4-carboxylate

HRID 2276008

反応式

HRID 2276008 の反応式
[Cl:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9](=O)[C:10](=[C:15]([NH:17]C)[CH3:16])[C:11]([O:13][CH3:14])=[O:12].[CH3:20][NH:21]N>C(OCC)C>[Cl:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[N:21]([CH3:20])[N:17]=[C:15]([CH3:16])[C:10]=1[C:11]([O:13][CH3:14])=[O:12]

参加物

4

反応物 2

HCID 6061MethylhydrazineHCID 178483602HCID 178483602、化合物2 回

生成物 1

HCID 66614282methyl 5-(2-chloro-4-fluorophenyl)-1,3-dimethyl-1H-pyrazole-4-carboxylate

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

A mixture of methyl 2-chloro-4-fluoro-α-[1-(methylamino)ethylidene]-β-oxobenzenepropanoate (i.e. the product of Step B) (15.91 g, 55.82 mmol) and methylhydrazine (3 mL, 56 mmol) in diethyl ether (150 mL) was stirred at room temperature for 48 h. The reaction mixture was concentrated under reduced pressure to provide the title compound as a colorless oil (15 g).

後処理

  1. concentrationThe reaction mixture was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-f68676f0122141afb3a00f2295293e75
出典データセット
uspto-grants-2015_09
特許番号
US09131693B2

関連ノート

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