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p-Nitroacetophenone → (2E)-1-(4-nitrophenyl)-3-pyridin-4-ylprop-2-en-1-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | p-Nitroacetophenone | HCID 7487 | — |
| 反応物 | 4-Pyridinecarboxaldehyde | HCID 13389 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Water ethanol | HCID 19096565 | — |
| 生成物 | (2E)-1-(4-nitrophenyl)-3-pyridin-4-ylprop-2-en-1-one | HCID 6088197 | 25.3% |
反応手順
A suspension of 4′-nitroacetophenone (5 g, 30.3 mmol) and 4-pyridinecarboxaldehyde (2.89 mL, 30.3 mmol) in water (45 mL) at room temperature was treated with 6% NaOH in H2O/ethanol (2:1)(0.606 mL), stirred overnight, and filtered. The filter cake was washed with water and small amount of ethanol then triturated with dichloromethane to provide 1.95 g (25%) of the desired product. MS(ESI(+)) m/e 255 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07560552B2 |
| 出典データセット | uspto-grants-2009_07 |
| ORD ID | ord-66be6540069849619d3c20efa2b68ca7 |
| 出典メモ | uspto-grants-2009_07 |