Bromine → HCID 69054306、化合物

HRID 227610ノート

反応式

HRID 227610 の反応式
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[C:18]3[C:17]([NH2:19])=[N:16][CH:15]=[N:14][C:13]=3[S:12][CH:11]=2)=[CH:6][CH:5]=1)([O-:3])=[O:2].[Br:20]Br>C(O)(=O)C.CN(C=O)C.C([O-])(O)=O.[Na+]>[Br:20][C:11]1[S:12][C:13]2[N:14]=[CH:15][N:16]=[C:17]([NH2:19])[C:18]=2[C:10]=1[C:7]1[CH:6]=[CH:5][C:4]([N+:1]([O-:3])=[O:2])=[CH:9][CH:8]=1

参加物

6

反応物 2

HCID 24408BromineHCID 597942485-(4-Nitrophenyl)thieno[2,3-d]pyrimidin-4-amine

生成物 1

HCID 69054306HCID 69054306、化合物

試薬・触媒・溶媒 3

HCID 176Acetic Acid溶媒HCID 6228Dimethylformamide溶媒HCID 516892Sodium Bicarbonate溶媒

反応条件

温度
0 °C

実験手順

A suspension of Example 58C (50 mg, 0.18 mmol) in acetic acid (1 mL) and DMF (3 mL) was heated with a heat gun to obtain a clear solution, cooled to 0° C., and treated with bromine (0.02 mL). The reaction mixture was stirred at 0° C. for 1 hour, diluted with saturated NaHCO3, and filtered. The filter cake was dried to provide 56 mg of the desired product.

後処理

  1. customto obtain a clear solution
  2. filtrationfiltered
  3. customThe filter cake was dried

出典と根拠

ORDレコード
ord-2ed0f528beef43c986ccabe2b2a9d6ea
出典データセット
uspto-grants-2009_07
特許番号
US07560552B2

反応ノート

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