化工社化工社 化学情報印刷レポート · 研究参考用
2-Aminothiazole → N-[2-(2,3-Dimethoxyphenoxy)phenyl]-N'-(thiazol-2-yl)urea
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Aminothiazole | HCID 2155 | — |
| 反応物 | 1-Fluoro-2-nitrobenzene | HCID 73895 | — |
| 反応物 | 2,3-Dimethoxyphenol | HCID 78828 | — |
| 反応物 | 2-(2,3-Dimethoxyphenoxy)aniline | HCID 66998935 | — |
| 生成物 | N-[2-(2,3-Dimethoxyphenoxy)phenyl]-N'-(thiazol-2-yl)urea | HCID 59732909 | 71% |
| 生成物 | 2-(2,3-Dimethoxyphenoxy)-1-nitrobenzene | HCID 66999086 | 64% |
反応手順
2-(2,3-Dimethoxyphenoxy)-1-nitrobenzene (0.88 g, 64%) was prepared from 2,3-dimethoxyphenol (0.85 g, 5.5 mmol) and 1-fluoro-2-nitrobenzene (0.71 g, 5.0 mmol) following the general procedure A. This was reduced to 2-(2,3-dimethoxyphenoxy)aniline (0.57 g, 73%) following general procedure B. N-[2-(2,3-Dimethoxyphenoxy)phenyl]-N′-(thiazol-2-yl)urea (131 g, 71%) was prepared from 2-(2,3-dimethoxyphenoxy)aniline (123 mg, 0.5 mmol) and 2-aminothiazole (60 mg, 0.6 mmol) following the general procedure D.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | USRE045670E1 |
| 出典データセット | uspto-grants-2015_09 |
| ORD ID | ord-c886655731924bc080dcfd04835998c1 |
| 出典メモ | uspto-grants-2015_09 |