化工社化工社 化学情報印刷レポート · 研究参考用
2-Aminothiazole → 1-(1-Methylethoxy)-2-nitrobenzene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Aminothiazole | HCID 2155 | — |
| 反応物 | Isopropanol | HCID 3776 | — |
| 反応物 | 2-(1-Methylethoxy)benzenamine | HCID 34436 | — |
| 反応物 | 1-Fluoro-2-nitrobenzene | HCID 73895 | — |
| 生成物 | 1-(1-Methylethoxy)-2-nitrobenzene | HCID 197180 | 70% |
| 生成物 | N-(2-Isopropoxyphenyl)-N'-thiazolylurea | HCID 47363733 | 60% |
反応手順
2-(Isopropoxy)-1-nitrobenzene (317 mg, 70%) was prepared from isopropyl alcohol (0.24 ml, 3.0 mmol) and 1-fluoro-2-nitrobenzene (0.36 g, 2.5 mmol) following the general procedure G. This was reduced to 2-(isopropoxy)aniline (198 mg, 75%) following general procedure B. N-(2-Isopropoxyphenyl)-N′-thiazolylurea (218 mg, 60%) was prepared from 2-(isopropoxy)aniline (198 mg, 01.3 mmol) and 2-aminothiazole (150 mg, 1.5 mmol) following the general procedure D.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | USRE045670E1 |
| 出典データセット | uspto-grants-2015_09 |
| ORD ID | ord-69d2c83747284e9093266df914744f44 |
| 出典メモ | uspto-grants-2015_09 |