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m-Tolylisothiocyanate → Thienopyrimidine deriv. 65
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | m-Tolylisothiocyanate | HCID 69304 | — |
| 反応物 | 5-(4-Aminophenyl)-6-methylthieno[2,3-d]pyrimidin-4-amine | HCID 6539968 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | Thienopyrimidine deriv. 65 | HCID 6539974 | 80% |
反応手順
A solution of Example 1E (60 mg, 0.23 mmol) and 3-methylphenyl isothiocyanate in DMF (2 mL) was stirred at room temperature, for 48 hours, quenched with water, and filtered. The filter cake was dried to provide the desired product (75 mg, 80%). MS(ESI(+)) m/e 406 (M+H)+; 1H NMR (300 MHz, DMSO-d6) δ 9.96 (s, 1H); 9.84 (s, 1H); 8.27 (s, 1H); 7.65 (d, J=8.4 Hz, 2H); 7.35 (d, J=8.4 Hz, 2H); 7.30-7.18 (m, 3H); 6.97 (d, J=6.9 Hz, 1H); 2.30 (s, 6H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07560552B2 |
| 出典データセット | uspto-grants-2009_07 |
| ORD ID | ord-e9e43410ddf145fcad3dadf6b8e5628a |
| 出典メモ | uspto-grants-2009_07 |