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2-(Trifluoromethyl)benzoic acid → N-{2-[3-chloro-5-(trifluoromethyl)-2-Pyridinyl]butyl}-2-(trifluoromethyl)benzamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-(Trifluoromethyl)benzoic acid | HCID 9899 | — |
| 反応物 | 2-[3-Chloro-5-(trifluoromethyl)-2-pyridinyl]-1-butanamine | HCID 16037439 | — |
| 反応物 | 4-(4,6-Dimethoxy[1.3.5]triazin-2-yl)-4-methylmorpholinium chloride hydrate | HCID 23149411 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | N-{2-[3-chloro-5-(trifluoromethyl)-2-Pyridinyl]butyl}-2-(trifluoromethyl)benzamide | HCID 86612328 | — |
反応手順
100 mg of 2-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]-1-butanamine (0.0004 mol), 58 μL of 2-(trifluoromethyl)benzoic acid(0.0004 mol), 0.109 g of 4-(4,6-dimethoxy[1.3.5]triazin-2-yl)-4-methylmorpholinium chloride hydrate (0.0004 mol) are stirred in 2 mL of ethanol at room temperature overnight.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07560567B2 |
| 出典データセット | uspto-grants-2009_07 |
| ORD ID | ord-4df16ea28b544249987f7ce2a0ad5b62 |
| 出典メモ | uspto-grants-2009_07 |