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Triethylamine → N-{2-(acetylamino)-2-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]ethy}-2-(trifluoromethyl)benzamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 2-(Trifluoromethyl)benzoic acid | HCID 9899 | — |
| 反応物 | 4-(4,6-Dimethoxy[1.3.5]triazin-2-yl)-4-methylmorpholinium chloride hydrate | HCID 23149411 | — |
| 反応物 | N-{2-amino-1-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]ethyl}acetamide trifluoroacetate | HCID 86612330 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | N-{2-(acetylamino)-2-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]ethy}-2-(trifluoromethyl)benzamide | HCID 86612329 | — |
反応手順
108 mg of N-{2-amino-1-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]ethyl}acetamide trifluoroacetate (0.0003 mol), 76 mg of 2-(trifluoromethyl)benzoic acid (0.0003 mol)), 83 mg of 4-(4,6-dimethoxy[1.3.5]triazin-2-yl)-4-methylmorpholinium chloride hydrate (0.0003 mol) and 41 μL of triethylamine (0.0003 mol) are stirred in 3 mL of ethanol at room temperature overnight.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07560567B2 |
| 出典データセット | uspto-grants-2009_07 |
| ORD ID | ord-289122d3fd244f40bcd2f2a126f0925d |
| 出典メモ | uspto-grants-2009_07 |