Potassium Carbonate → HCID 11704773、化合物

HRID 227662ノート

反応式

HRID 227662 の反応式
[N:1]1([C:10]2[S:11][C:12]([C:27]([NH2:29])=[O:28])=[C:13]([O:15][CH2:16][C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[C:23]([F:26])([F:25])[F:24])[N:14]=2)[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[CH:2]1.ClC1SC(C(N)=O)=C(OCC2C=CC=CC=2C(F)(F)[F:45])N=1.FC1C=CC2N=CNC=2C=1.C([O-])([O-])=O.[K+].[K+]>CN(C=O)C>[F:45][C:7]1[CH:8]=[CH:9][C:4]2[N:3]=[CH:2][N:1]([C:10]3[S:11][C:12]([C:27]([NH2:29])=[O:28])=[C:13]([O:15][CH2:16][C:17]4[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=4[C:23]([F:26])([F:25])[F:24])[N:14]=3)[C:5]=2[CH:6]=1

参加物

6

反応物 4

HCID 11430Potassium CarbonateHCID 2356985-FluorobenzimidazoleHCID 115389692-(1H-Benzimidazol-1-yl)-4-({[2-(trifluoromethyl)phenyl]methyl}-oxy)-1,3-thiazole-5-carboxamideHCID 57756681HCID 57756681、化合物

生成物 1

HCID 11704773HCID 11704773、化合物

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

Following the procedure described above for the preparation of 2-(1H-benzimidazol-1-yl)-4-({[2-(trifluoromethyl)phenyl]methyl}oxy)-1,3-thiazole-5-carboxamide using the following materials: 2-chloro-4-({[2-(trifluoromethyl)phenyl]methyl}oxy)-1,3-thiazole-5-carboxamide (0.050 g, 0.14 mmol), 5-fluorobenzimidazole (0.011 g, 0.08 mmol), K2CO3 (0.011 g, 0.08 mmol) and DMF (4 mL). Data for 6 regioisomers: 1H NMR (400 MHz, CDCl3) δ 8.46 (s, 1H), 7.82-7.74 (m, 2H), 7.69-7.58 (m, 3H), 7.54-7.50 (m, 1H), 7.16 (td, J=9.1, 2.4 Hz, 1H), 6.80 (bs, 1H), 5.82 (s, 2H), 5.76 (bs, 1H). MS m/z 437 (m+1).

出典と根拠

ORDレコード
ord-fe4511be6e774e46a857efc0d9271968
出典データセット
uspto-grants-2009_07
特許番号
US07560568B2

反応ノート

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