Propionic Acid → 4-Hydroxy-6-methyl-3-propionyl-2H-pyran-2-one
反応式
[OH:1][C:2]1[CH:7]=[C:6]([CH3:8])[O:5][C:4](=[O:9])[CH:3]=1.C1CCC(N=C=NC2CCCCC2)CC1.[C:25](O)(=[O:28])[CH2:26][CH3:27]>C(Cl)Cl.CN(C1C=CN=CC=1)C>[OH:1][C:2]1[CH:7]=[C:6]([CH3:8])[O:5][C:4](=[O:9])[C:3]=1[C:25](=[O:28])[CH2:26][CH3:27]参加物
6
反応条件
- 温度
- 0 °C
実験手順
To 4-hydroxy-6-methyl-2H-pyran-2-one (18 g; 143 mmol; Aldrich) in 300 ml DCM at 0° C., was added TEA (20 ml; 143 mmol; Aldrich), DCC (30 g; 145 mmol; Aldrich), DMAP (5.25 g; 42.7 mmol; Aldrich) and propionic acid (11 ml; 147 mmol; Aldrich). The reaction mixture was stirred at 0° C. for 1 h, stirred at 25° C. for 18 h, and filtered via vacuum filtration. The filtrate was washed with 5% HCl, dried with brine and anhydrous Na2SO4, and evaporated to a white solid.
後処理
- stirringstirred at 25° C. for 18 h
- filtrationfiltered via vacuum filtration
- washThe filtrate was washed with 5% HCl
- dry with materialdried with brine and anhydrous Na2SO4
- customevaporated to a white solid
出典と根拠
- ORDレコード
- ord-b104cc87cde049c7a8aa209a042c83f0
- 出典データセット
- uspto-grants-2015_09
- 特許番号
- US09133155B2
反応ノート
読み込み中…