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Acetic Anhydride → 2-Acetamido-4-fluorotoluene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetic Anhydride | HCID 7918 | — |
| 反応物 | 5-Fluoro-o-toluidine | HCID 67774 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 2-Acetamido-4-fluorotoluene | HCID 3523118 | 82% |
反応手順
5-Fluoro-2-methylaniline (10.0 g, 79.9 mmol, 1 equiv) was dissolved In toluene (50 mL) and placed in a cool water bath. Acetic anhydride (11.3 mL, 120 mmol, 1.5 equiv) was added slowly. After 15 minutes, a white precipitate had formed. The solid was collected by filtration and washed with toluene several times, affording 10.93 g (82%) of the title compound as a white crystalline solid. MS (ES+) m/e 213 [M+H].
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07560467B2 |
| 出典データセット | uspto-grants-2009_07 |
| ORD ID | ord-ba22637887ac4a49983b482361708f69 |
| 出典メモ | uspto-grants-2009_07 |