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HRID 2277230作成日：2026年10月27日

(2,2-Difluorocyclopropyl)methanol → N-((2S)-1-((2-(4-((2,2-difluorocyclopropyl)methoxy)-2,5-difluorophenyl)[1,3]oxazolo[4,5-c]pyridin-6-yl)oxy)propan-2-yl)acetamide

https://huagongshe.com/reaction/2277230

反応式

関与物質

役割名称HCID仕込み量
反応物(2,2-Difluorocyclopropyl)methanolHCID 2761401—
反応物N-((2S)-1-((2-(4-(benzyloxy)-2,5-difluorophenyl)[1,3]oxazolo[4,5-c]pyridin-6-yl)oxy)propan-2-yl)acetamideHCID 86731302—
生成物N-((2S)-1-((2-(4-((2,2-difluorocyclopropyl)methoxy)-2,5-difluorophenyl)[1,3]oxazolo[4,5-c]pyridin-6-yl)oxy)propan-2-yl)acetamideHCID 86731301—

反応手順

Using N-((2S)-1-((2-(4-(benzyloxy)-2,5-difluorophenyl)[1,3]oxazolo[4,5-c]pyridin-6-yl)oxy)propan-2-yl)acetamide and (2,2-difluorocyclopropyl)methanol, and in the same manner as in Step A and Step B of Example 4, the title compound was obtained.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US09133129B2
出典データセットuspto-grants-2015_09
ORD IDord-9469dbca968d458a814062308f406bfd
出典メモuspto-grants-2015_09