5-Bromo-2-(cyclopropylmethoxy)pyrimidine → N-((2S)-1-((2-(2-(cyclopropylmethoxy)pyrimidin-5-yl)-1,3-benzoxazol-6-yl)oxy)propan-2-yl)acetamide
反応式
Br[C:2]1[CH:3]=[N:4][C:5]([O:8][CH2:9][CH:10]2[CH2:12][CH2:11]2)=[N:6][CH:7]=1.[O:13]1[C:17]2[CH:18]=[C:19]([O:22][CH2:23][C@@H:24]([NH:26][C:27](=[O:29])[CH3:28])[CH3:25])[CH:20]=[CH:21][C:16]=2[N:15]=[CH:14]1>>[CH:10]1([CH2:9][O:8][C:5]2[N:4]=[CH:3][C:2]([C:14]3[O:13][C:17]4[CH:18]=[C:19]([O:22][CH2:23][C@@H:24]([NH:26][C:27](=[O:29])[CH3:28])[CH3:25])[CH:20]=[CH:21][C:16]=4[N:15]=3)=[CH:7][N:6]=2)[CH2:12][CH2:11]1参加物
3
実験手順
Using 5-bromo-2-(cyclopropylmethoxy)pyrimidine and N-((2S)-1-(1,3-benzoxazol-6-yloxy)propan-2-yl)acetamide, and in the same manner as in Step B of Example 22, the title compound was obtained.
出典と根拠
- ORDレコード
- ord-c2de321a6e5f4dfca896131783bbf4e8
- 出典データセット
- uspto-grants-2015_09