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Thionyl Chloride → 7-(Benzyloxy)-4-chloro-6-methoxyquinazoline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Thionyl Chloride | HCID 24386 | — |
| 反応物 | 7-Benzyloxy-6-methoxy-3H-quinazolin-4-one | HCID 135404718 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 7-(Benzyloxy)-4-chloro-6-methoxyquinazoline | HCID 10661998 | — |
反応手順
A mixture of 7-benzyloxy-6-methoxy-3,4-dihydroquinazolin-4-one (35 g), thionyl chloride (440 ml) and DMF (1.75 ml) was heated to reflux for 4 hours. The thionyl chloride was evaporated under vacuum and the residue was azeotroped with toluene three times. The residue was dissolved in N-methylpyrrolidin-2-one (250 ml) to give a solution of 7-benzyloxy-4-chloro-6-methoxyquinazoline.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06849625B2 |
| 出典データセット | uspto-grants-2005_02 |
| ORD ID | ord-b4c03b330592499e868eec12a39db24a |
| 出典メモ | uspto-grants-2005_02 |