Thionyl Chloride → 7-(Benzyloxy)-4-chloro-6-methoxyquinazoline

HRID 22774

反応式

HRID 22774 の反応式
[CH2:1]([O:8][C:9]1[CH:18]=[C:17]2[C:12]([C:13](=O)[NH:14][CH:15]=[N:16]2)=[CH:11][C:10]=1[O:20][CH3:21])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.S(Cl)([Cl:24])=O>CN(C=O)C>[CH2:1]([O:8][C:9]1[CH:18]=[C:17]2[C:12]([C:13]([Cl:24])=[N:14][CH:15]=[N:16]2)=[CH:11][C:10]=1[O:20][CH3:21])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 1354047187-Benzyloxy-6-methoxy-3H-quinazolin-4-one

生成物 1

HCID 106619987-(Benzyloxy)-4-chloro-6-methoxyquinazoline

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

A mixture of 7-benzyloxy-6-methoxy-3,4-dihydroquinazolin-4-one (35 g), thionyl chloride (440 ml) and DMF (1.75 ml) was heated to reflux for 4 hours. The thionyl chloride was evaporated under vacuum and the residue was azeotroped with toluene three times. The residue was dissolved in N-methylpyrrolidin-2-one (250 ml) to give a solution of 7-benzyloxy-4-chloro-6-methoxyquinazoline.

後処理

  1. temperaturewas heated
  2. temperatureto reflux for 4 hours
  3. customThe thionyl chloride was evaporated under vacuum
  4. customthe residue was azeotroped with toluene three times
  5. dissolutionThe residue was dissolved in N-methylpyrrolidin-2-one (250 ml)

出典と根拠

ORDレコード
ord-b4c03b330592499e868eec12a39db24a
出典データセット
uspto-grants-2005_02
特許番号
US06849625B2

関連ノート

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