1-Bromo-3-chloropropane → 4-(3-Chloropropyl)morpholine

HRID 22775

反応式

HRID 22775 の反応式
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.Br[CH2:8][CH2:9][CH2:10][Cl:11]>C1(C)C=CC=CC=1>[O:4]1[CH2:5][CH2:6][N:1]([CH2:8][CH2:9][CH2:10][Cl:11])[CH2:2][CH2:3]1

参加物

4

反応物 2

HCID 80061-Bromo-3-chloropropaneHCID 8083Morpholine

生成物 1

HCID 958344-(3-Chloropropyl)morpholine

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

反応条件

温度
70 °C

実験手順

A mixture of morpholine (52.2 ml), 1-bromo-3-chloropropane (30 ml) and toluene (180 ml) was heated to 70° C. for 3 hours. The solid was removed by filtration and the filtrate was evaporated under vacuum. The resultant oil was decanted from the additional solid which was deposited and the oil was purified by vacuum distillation to yield 3-morpholinopropyl chloride (37.91 g); NMR Spectrum: (DMSOd6) 1.85 (m, 2H), 2.3 (t, 4H), 2.38 (t, 2H), 3.53 (t, 4H), 3.65 (t, 2H).

後処理

  1. customThe solid was removed by filtration
  2. customthe filtrate was evaporated under vacuum
  3. customThe resultant oil was decanted from the additional solid which
  4. distillationthe oil was purified by vacuum distillation

出典と根拠

ORDレコード
ord-a049d93aa79344ffb2fda0463cf54c65
出典データセット
uspto-grants-2005_02
特許番号
US06849625B2

関連ノート

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