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Sodium Hydroxide → US10273222, Example 99
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 2-bromo-2,3-dihydro-1H-indene | HCID 10965463 | — |
| 反応物 | methyl 2-(1H-imidazol-4-yl)pyridine-4-carboxylate | HCID 178498395 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | US10273222, Example 99 | HCID 86269492 | 48% |
反応手順
The title compound was prepared in 48% yield from methyl 2-(1H-imidazol-4-yl)pyridine-4-carboxylate (PREPARATION 5) and 2-bromo-2,3-dihydro-1H-indene according to the procedure for the preparation of Example 44, followed by saponification using NaOH in MeOH. 1HNMR (400 MHz, DMSO): δ 2.21 (2H, d), 3.52 (2H, d), 5.22 (1H, m), 7.23 (2H, m), 7.32 (2H, m), 7.45 (1H, t, J=5.4 Hz), 7.59 (1H, s), 7.82 (1H, s), 8.21 (1H, s), 8.35 (1H, d). [M+H] Calc'd for C18H15N3O2, 306. Found, 306.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09133166B2 |
| 出典データセット | uspto-grants-2015_09 |
| ORD ID | ord-5e58d9975f7f408c97cab71c68482c13 |
| 出典メモ | uspto-grants-2015_09 |