(2-Butoxy-4-fluorophenyl)boronic acid → HCID 90407314、化合物

反応式

Br[C:2]1[N:6]([CH3:7])[CH:5]=[N:4][C:3]=1[C:8]1[CH:13]=[C:12]([C:14]#[N:15])[CH:11]=[CH:10][N:9]=1.[CH2:16]([O:20][C:21]1[CH:26]=[C:25]([F:27])[CH:24]=[CH:23][C:22]=1B(O)O)[CH2:17][CH2:18][CH3:19]>>[CH2:16]([O:20][C:21]1[CH:26]=[C:25]([F:27])[CH:24]=[CH:23][C:22]=1[C:2]1[N:6]([CH3:7])[CH:5]=[N:4][C:3]=1[C:8]1[CH:13]=[C:12]([C:14]#[N:15])[CH:11]=[CH:10][N:9]=1)[CH2:17][CH2:18][CH3:19]

参加物

反応物 2

HCID 16217204(2-Butoxy-4-fluorophenyl)boronic acid

HCID 904081442-(5-Bromo-1-methylimidazol-4-yl)pyridine-4-carbonitrile

生成物 1

HCID 90407314HCID 90407314、化合物

実験手順

The title compound was prepared from 2-(5-bromo-1-methyl-1H-imidazol-4-yl)pyridine-4-carbonitrile (PREPARATION 2) and 2-butoxy-4-fluorophenylboronic acid according to the procedure for the preparation of Example 3, part A. [M+H] Calc'd for C20H19FN4O, 351. Found, 351.

出典と根拠

ORDレコード: ord-1ecea69443324f0aa6330e0c73d62ed9
出典データセット: uspto-grants-2015_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09133166B2

反応ノート

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