Phosphorus tribromide → 1-(Bromomethyl)-3-chloro-2-fluorobenzene

HRID 2277576ノート

反応式

HRID 2277576 の反応式
[Cl:1][C:2]1[C:3]([F:10])=[C:4]([CH2:8]O)[CH:5]=[CH:6][CH:7]=1.P(Br)(Br)[Br:12]>C(Cl)Cl>[Br:12][CH2:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[C:3]=1[F:10]

参加物

4

反応物 2

HCID 24614Phosphorus tribromideHCID 27736063-Chloro-2-fluorobenzyl alcohol

生成物 1

HCID 5228271-(Bromomethyl)-3-chloro-2-fluorobenzene

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of (3-chloro-2-fluoro-phenyl)-methanol (3.2 g, 20 mmol) in DCM (20 mL) was added dropwise PBr3 (1 mL) at 0° C. The reaction mixture was stirred at room temperature for another 1 hour before quenching with satd. aq. NaHCO3 solution. The organic layer was washed with brine, dried over anhy. Na2SO4, filtered and concentrated in vacuo to give the desired product without further purification (4.1 g, 92%). MS: 223.2 (M+H)+.

後処理

  1. custombefore quenching with satd
  2. washThe organic layer was washed with brine
  3. customdried over anhy
  4. filtrationNa2SO4, filtered
  5. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-83f5b1b3b60342609dee565456a80b17
出典データセット
uspto-grants-2015_09
特許番号
US09133158B2

反応ノート

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